COMPUTATIONAL MODELING DRIVES SELECTIVITY OF CRL4 CRBN RECRUITING PROTACs
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Selectivity is still a major challenge in the design of CRL4CRBN recruiting PROTACs.
- Prediction of key interactions mediating the formation of productive ternary complexes can overcome the selectivity issues.
- Using structural insights from known neo-substrates, degron blocking design principles, and computational modelling lead to an analogue with an improved selectivity profile.